Ryan's practice focuses on advising large and small companies on all aspects of business, including formation or reorganization, contracts, raising capital, compliance with federal and state securities laws and resolving commercial disputes through arbitration or litigation. Ryan also helps clients to register, protect and enforce their intellectual property rights in trademarks, copyrights and domain names in the United States and internationally. Among the clients Ryan represents are entrepreneurs and established businesses in the automotive, financial services, real estate, technology, transportation, health care and hospitality industries, as well as many other unique enterprises. He also advises clients in the entertainment industry regarding copyright, licensing and royalty issues.

Ryan has practiced before trial and appellate courts in Pennsylvania, Maryland and New Jersey, as well as various agencies including the United States Trial and Trademark Appeal Board, the World Intellectual Property Organization, the Pennsylvania Public Utilities Commission, the Pennsylvania Liquor Control Board and local zoning hearing boards. He also serves as an arbitrator for the Court of Common Pleas of Cumberland County and York County, Pennsylvania.

Ryan is an assistant editor of the Vindobona Journal of International Commercial Law and Arbitration. He regularly contributes articles to various industry and legal publications.